With Opdivo-Yervoy combo, Bristol Myers calls Roche and AstraZeneca's bets in first-line liver cancer
Bristol Myers Squibb's Opdivo and Yervoy helped 38% of patients with newly diagnosed liver cancer live past three years in a phase 3 trial, setting a new record.
Median progression-free survival was similar between the arms at 9.1 months with nivolumab plus ipilimumab compared with 9.2 months with lenvatinib or sorafenib. However, the progression-free survival rates were higher with the combination at 18 months (34% vs 18%) and 24 months (28% vs 12%).
he primary endpoint was overall survival (OS). Secondary endpoints included objective response rate (ORR) and duration of response (DOR) per blinded independent central review (BICR) using RECIST v1.1.
"What this study does primarily is give us 3 options to think about in the first-line setting that have all beaten the previous standard.”